The discomfort starts strong right out of the gate in the first episode, in which Galifianakis basically molests Michael Cera. There is a common thread of one-sided sexual tension in many of the episodes, and certainly not just with the female guests, though it may be strongest in the episode featuring Natalie Portman. It is a testament to her skill as an “acteress” that this episode is one of the most authentic, as if she were actually just in the midst of a nightmarish interview set up by the most incompetent agent imaginable. Other episodes are more clearly staged, and perhaps the weakest is the one with Will Ferrell, if only because the two are generally too chummy with each other, at least until the end.

The series is at its best when Galifianakis is openly hostile to his guests, like the episodes featuring Ben Stiller and “Brad Lee Cooper.” Though this hostility is common throughout the series, only “Conan O. Brien” gets an explanation, which is that Galifianakis thought he had a shot at “The Tonight Show.” Another especially convincing episode features Galifianakis’ “twin brother,” Seth, interviewing a wooden-faced Sean Penn, who really seems like he might haul off and punch Galifianakis at any moment. As with Portman, it is Penn’s acting skill that pulls off the joke so well.

A pitch-perfect spoof of bad, desperate public access talk shows, “Between Two Ferns” is easily one of the best offerings from the always enjoyable Funny or Die. Even the opening and closing theme music feels authentic, though it is actually lifted from Bernard Herrmann‘s “Taxi Driver” score, which adds to Galifianakis’ creepy, angry vibe. I’m not sure how well it would work as a full-length show on television, but in the small segments available online, it is hilarious.

The first episode features Mark Gagliardi recounting the story of Alexander Hamilton’s famous duel with Aaron Burr after drinking a bottle of Scotch. Though it is unclear how large the bottle was, it was clearly quite a bit of liquor, as he spends most of his segment reclined on a couch with a bucket nearby, just in case. Hamilton is played by a suitably innocent-looking Michael Cera in the reenactment, but the real show-stealer is Jake Johnson in a brilliantly shifty-eyed performance as the loathsome Aaron Burr. In episode 2, Eric Falconer takes on the famous story of Benjamin Franklin‘s discovery of electricity, expounding upon his theory that it was actually Franklin’s “bastard son,” William (Clark Duke), who actually flew the legendary kite with the key tied to it. This is also the series’ first instance of vomiting in the midst of the storytelling, but not its last, so be warned that the series is not for the weak-stomached. Jack Black portrays Franklin again in a special volume 2.5 episode, in which Falconer tells a hilarious tale of Franklin’s sexual deviance.

Episode 3 features Jen Kirkman‘s account of Oney Judge (Tymberlee Hill), a female slave of George Washington (Danny McBride) that is especially funny because of the way the actors incorporate Kirkman’s frequent hiccups into their performances. The fourth episode features J.D. Ryznar‘s unwise decision to drink vodka and beer together, which obviously leads to more vomiting, and his account of the U.S. president William Henry Harrison (Paul Schneider), who died after only 32 days in office. Jen Kirkman returns for episode 5, in which Don Cheadle gives a hilarious performance as Frederick Douglass; there is something especially funny about Kirkman’s slurred words coming out of this revered actor’s mouth. Finally, in episode 6, Duncan Trussell follows six beers with a half-bottle of absinthe, and more vomiting ensues. He also tells the story of Nikola Tesla (John C. Reilly) and his contentious relationship with Thomas Edison (the always intensely weird Crispin Glover).

These are the only official episodes of the series (plus a very special Christmas episode included below), so beware of the unofficial knockoffs, most of which are pretty terrible. In fact, the one I linked to there is pretty much the only one that’s watchable, and it’s still nowhere near as good as the real thing. In addition to the recognizable stars, look for Waters’ name and also that of series director Jeremy Konner to avoid being duped.

Our own Jessica Hall is featured as the Lollipop Girl in this funny video from the gang at Funny or Die. Check it out as Will Ferrell’s little brother sings to our Featured Model from 2007.