Bullz-Eye: Just the fact that “Men at Work” has gotten a second season, period, has got to be pretty thrilling in and of itself, but how was it to go back to work for season two?

Danny Masterson: You know, it’s funny: we actually only took about six weeks off, so we didn’t feel like we had a whole summer hiatus. We just took six weeks, and then we kept going with the same director and same crew, so it just feels like a really long first season that we’ve shot. We just had a lot of excellent new guest stars, I guess.

BE: Yeah, the list is pretty impressive.

DM: Thanks! I think it’s sort of a benefit of having both Breckin (Meyer) and I both working since we were little kids. We’ve worked with a lot of people who are known actors, so it’s fun to sort of bring those friends in to work with you for a bit.

BE: When you guys came onto the series, how well-defined were the characters on the page versus what they became once they were actually cast?

DM: You know, I think they were pretty well defined. Breckin sort of based them off…well, he based my character, Milo, off himself. [Laughs.] And the three friends are based off of his three best friends. So pretty much everybody knew exactly who they were in the beginning. And then, obviously, as you’re going through the episodes, you sort of change your characters a little bit to make them suited towards you a little bit, just in terms of everyone’s own personalities. But I’d say 95% is exactly how Breckin wrote it to begin with.

BE: Did the cast bond pretty quickly?

DM: Yeah, I’d say so. I’ve known James Lesure for…I dunno, maybe 10 years. I hadn’t met Adam (Busch) or (Michael) Cassidy before, but, y’know, right from the table read everyone was really excited to have a really cool job, so… I get along with everybody, and they’re all really great people. Three totally different personalities, but we’ve never had a single fight. I mean, it’s only been two years, obviously, so we’ll probably wrestle at some point. [Laughs.] But they’re really fun. Everyone’s really stoked to have a good job, we all enjoy it, and as long as the writing stays good – and the writing’s been really good – I think we’ll all stay really happy.

BE: Speaking of writing, as a writer, I have to wonder how many times you’ve heard from various critics that, uh, not many magazine offices tend to run the way the one on “Men at Work” does.

DM: [Sighs.] Um…y’know, honestly, we’re entertaining people. We’re doing a situation comedy. We’re just there to make people laugh. So…I mean, it’d be like every lawyer watching “L.A. Law” and going, “You know, that’s not really what court’s like.” [Laughs.] It’s just one of those things..

BE: As you mentioned, you’ve got several new guest stars coming up for season two, but who were your favorites from season one?

DM: Y’know, it was super fun, obviously, working with (Laura) Prepon again, having spent eight years with her (on “That ‘70s Show”), so that was just sort of, like, every time we would say, “Cut,” we’d just start laughing. It was, like, “Oh, my God, this is ridiculous. This is just like what we used to do together.” And then, for me, working with Kevin Pollak, who I’m just such a massive fan of and who’s a friend of mine, but it’s still, like, “I can’t believe I get to be friends with Kevin Pollak!” [Laughs.] So to get to do that episode with him, the scene about the toilet bowl, was definitely a highlight. And it was probably the only scene that year that I had a hard time getting through. I just kept breaking and laughing every time. It was great.

BE: I was surprised that your brother (Christopher Masterson) turned up on the show playing someone other than your character’s brother. Was that just deemed too obvious?

DM: Well, y’know, it’s one of those things where the scripts come out and Breckin says, “Oh, we have this role for someone and that role for someone,” and when he said, “We have this role for this really strange, weird guy…” It could’ve been any kind of character. We didn’t know what Chris was gonna do when he came in. The character was not supposed to have an accent of any sort or…be any sort of persuasion or anything. [Laughs.] He just came in and, at the first rehearsal, just started doing that character, and everyone started laughing. That’s basically what happened.

BE: To bring it to season two, would you say that Milo has changed at all since we saw him in Season 1?

DM: Yeah, I’d say so. In season two, we have a really good relationship arc with Sarah Wright that’s really funny, where he goes from not being able to handle chatting with girls, then all of a sudden he has this girlfriend that he doesn’t know what to do with. And they very quickly become a very boring relationship that seems like they’ve been together for 20 years, even though they’ve only been together for a few weeks. So that was fun playing the exact opposite of season one. Otherwise, you know, it’s sort of the same thing in terms of Milo doing something kind of stupid and the guys sort of getting on him. He does something idiotic, and the other three pounce on him. That’s what’s been the most fun to do, character-wise.

BE: It’s great to see that you’ve brought back J.K. Simmons for this season.

DM: Oh, yeah, he’s done a few episodes, and he’s in the season finale. He’s so funny, and getting to work with him is amazing.

BE: How much of the show is scripted, and how much of an opportunity do you have to adlib?

DM: There’s basically zero adlibbing.

BE: Really?

DM: Yeah. Y’know, there are certain shows where there’s a lot of improv, and there are shows where there isn’t. When I was doing “That ‘70s Show,” Bonnie and Terry Turner kind of beat improv out of us. [Laughs.] We’ll definitely have…we’ll shoot a scene twice, and then if there are any jokes where it’s, like, “Let’s try this,” or, “I have a joke!” Everybody pitches everybody jokes, you pitch the writers, the writers pitch you, and if you find something that’s funny, then you might do two or three different pick-ups with alternate jokes. But that’s not really improv. That’s like being in the writer’s room, and then you go ahead and perform it. There’s never really any sort of curveball thrown. And that makes it easier, really, because you don’t have everybody trying to do one-ups and shit. The writers do their jobs, and as actors, we do our jobs.

BE: Setting aside “Men at Work,” what would you say is your favorite project you’ve worked on over the years that didn’t get the love you thought it deserved?

DM: Um…that’s a good question. I would say the movie “The Brooklyn Heist,” which I made in New York and produced. I thought that turned out really, really good. Y’know, we got a small theatrical release in New York, but a lot of people haven’t seen it. I don’t think it’s ever gotten a TV deal. It seems like these days you make a movie and…it used to be that people would see it on HBO or Showtime years later, but that doesn’t seem to happen as much anymore. I think it’s because of iTunes and downloads and all that stuff. But I think that movie, for the amount we shot it for and the way that it was shot, genre-wise, it was really, really smart. So, yeah, “The Brooklyn Heist,” that’d probably be my one that people would enjoy.

BE: You know, “Star Kid” is now on Netflix on Demand.

DM: Wow. You know, I’ve never actually seen that. What do I have, like, one scene in that movie? [Laughs.]

BE: Not significantly more than that, anyway.

DM: Ashlee Levitch, who plays the older sister in that movie, used to be a very good friend of mine. I haven’t seen her in probably 15 years, but when we were teenagers, she was always on a show, I was always on a show, so she called and said, “Hey, I’m doing this movie with the kid from ‘Jurassic Park’ (Joseph Mazzello), would you come play my boyfriend? It’s just for a scene or two.” So I said, “Yeah, okay, sure!” That’s literally how I got that movie. I never even saw the script. But I remember it was actually called “The Warrior of Waverly Street” when I signed onto it.

BE: You did some film work after “That ‘70s Show,” but do you enjoy returning to the routine of series television?

DM: Oh, yeah, I love it. And I definitely wasn’t looking to do a drama. I did a one-hour drama when I was 18, and it’s just such a brutal lifestyle. I mean, that’s a schedule that…most actors who are on one-hour dramas are leads, which means no life for 10 months out of the year, and if it goes for 10 years, then that’s sort of who you are. For me, doing a sitcom is…I mean, toward the end of “That ‘70s Show,” we were working 20 hours a week to get the show together, but on “Men at Work,” we’re obviously working a lot longer, because it’s newer and not everybody knows what they’re doing exactly…including myself, because we’re all still sort of getting to know each other. But it’s basically just summer camp all day, every day. You’re literally just rehearsing to make each other laugh, making fun of each other, and trying to get it ready to do it in front of a live audience. There’s really no better job in show business.

Robin Tunney (Ep. 1.1, “Pilot”)
Character: a kindergarten teacher who becomes dysphasic and starts having seizures. Turns out she’s invested with tapeworms.

Sam Trammell (Ep. 1.4, “Maternity”)
Character: the father of a baby girl that’s not even out of the maternity ward and already on death’s door from a virus.

Elizabeth Mitchell (Ep. 1.5, “Damned If you Don’t”)
Character: a nun who looks like she’s suffering from stigmata but is later discovered to be suffering an allergic reaction to a copper cross IUD left over from her, uh, wilder days.

Dominic Purcell (Ep. 1.6, “Fidelity”)
Character: a husband whose wife – the Patient of the Week – turns out to have been unfaithful.

Amanda Seyfried (Ep. 1.11, “Detox”)
Character: girlfriend to the Patient of the Week.

Scott Foley (Ep. 1.12, “Sports Medicine”)
Character: a baseball player suffering cadmium poisoning from all the pot he’s been smoking.

Joe Morton (Ep. 1.17, “Role Model”)
Character: a senator suffering the after-effects of an epilepsy treatment from childhood

John Cho (Ep. 1.20, “Love Hurts”)
Character: a guy who, after spilling apple juice on House’s clothes, ends up being diagnosed by him as having had a stroke. Upon further investigation, it’s determined that he has a trauma-induced aneurysm as a result of a preference for sadomasochism.

Carmen Electra (Ep. 1.21, “Three Stories”)
Character: While begrudgingly lecturing a classroom of medical students about a past patient who is depicted as looking like Carmen Electra playing miniature golf. In reality, the patient was actually a male golfer…and he played regular golf, by the way. (Who knew miniature golf could be so sexy?)

LL Cool J (Ep.2.1, “Acceptance”)
Character: a death-row inmate suffering from pheochromocytoma.

Ron Livingston (Ep. 2.4, “TB or Not TB”)
Character: a famous doctor who thinks he has tuberculosis. He doesn’t. It’s actually a tumor and a pancreas problem.

Taraji P. Henson (Ep. 2.6, “Spin”)
Character: the publicist for a famous bicyclist.

Cynthia Nixon (Ep. 2.9, “Deception”)
Character: an anemic woman who turns out to suffer from Münchausen’s syndrome.

Elle Fanning (Ep. 2.11, “Need to Know”)
Character: a little girl whose mom is swiping her Ritalin.

Howard Hesseman (Ep. 2.14, “Sex Kills”)
Character: a man who, in addition to suffering from a brain infection, is also sleeping with his ex-wife, who’s estranged from their daughter. It’s a family affair!

Michelle Trachtenberg (Ep. 2.16, “Safe”)
Character: a teenage girl who, in addition to having survived a car accident only by having a heart transplant, ends up suffering from an acute case of Tick in the Vagina. I only wish I was joking.

Jayma Mays (Ep. 2.18, “Sleeping Dogs Lie”)
Character: a poor, sweet girl who’s contracted bubonic plague through the fleas of her dog.

Thomas Dekker (Ep. 2.19, “House vs. God”)
Character: a faith healer who, rather embarrassingly, turns out to be suffering from a nasty case of herpes.

William Katt (Ep. 2.19, “House vs. God”)
Character: the father of the aforementioned faith healer.

D.B. Sweeney (Ep. 2.23, “Who’s Your Daddy?”)
Character: an old buddy of House’s who finds himself in the midst of a Katrina-related paternity situation.

Elias Koteas (Ep. 2.24, “No Reason”)
Character: a former patient of House’s who’s so disgruntled that he storms into the hospital and promptly shoots House twice. Which, really, isn’t all that surprising.

Kathleen Quinlan (Ep. 3.1, “Meaning”)
Character: the wife of a brain cancer surgery patient who’s paralyzed and in a wheelchair.

Sheryl Lee (Ep. 3.2, “Cane and Able”)
Character: the mother of a seven-year-old boy suffering from rectal bleeding and claims of being tortured by aliens.

Joel Grey (Ep. 3.3, “Informed Consent”)
Character: a noted cancer doctor who, as a result of suffering from the disease himself, begs House for euthanasia.

John Larroquette (Ep. 3.7, “Son of Coma Guy”)
Character: a gentleman in a vegetative state who, thanks to a cocktail of L-Dopa and amphetamines, is awakened long enough to reconnect with his son.

Patrick Fugit (Ep. 3.8, “Whac-A-Mole”)
Character: an 18-year-old who has a heart attack because, as it turns out, he needs a bone marrow transplant.

Meagan Good (Ep. 3.11, “Words and Deeds”)
Character: a firefighter who stands beside one of her medically-challenged coworkers

Dave Matthews (Ep. 3.15, “Half-Wit”)
Character: a pianist deals with a neurological condition which may impair his ability to play.

Kurtwood Smith (Ep. 3.15, “Half-Wit”)
Character: the father of the aforementioned pianist.

Marc Blucas (Ep. 3.16, “Top Secret”)
Character: a veteran who claims to have a nasty case of Gulf War Syndrome but is actually stuck with hereditary hemorrhagic telangiectasia instead.

Bailee Madison (Ep. 3.19, “Act Your Age”)
Character: a six-year-old who’s been affected by their father’s sexual-enhancement cream and, as a result, is going through puberty early.

Lyndsy Fonseca (Ep. 3.22, “Resignation”)
Character: a 19-year-old martial artist drinks drain cleaner and then pretends she hasn’t.

Piper Perabo (Ep. 3.22, “Resignation”)
Character: a vegan and nutritionist who thinks House is interested in her for a job and then gets upset when she realizes it’s more about her, uh, other assets.

Frank Whaley (Ep. 4.5, “Mirror, Mirror”)
Character: a mystery man who comes into the hospital and claims to have numerous symptoms while also suffering from some real ones.

Jeremy Renner (Ep. 4.9, “Games”)
Character: a grunge rocker whose addition to heroin is the least of his problems.

Mira Sorvino (Ep. 4.11, “Frozen”)
Character: a researcher in Antarctica who has to be diagnosed by House via webcam.

Felicia Day (Ep. 5.2, “Not Cancer”)
Character: a teacher who had a corneal transplant and is now dealing with a major brain problem.

Breckin Meyer (Ep. 5.3, “Adverse Events”)
Character: an artist who suffers from a gastrointestinal mass after taking an experimental antacid.

Sherilyn Fenn (Ep. 5.11, “Joy to the World”)
Character: the mother of a teenage girl suffering from both pregnancy and terminal cancer.

Judy Greer (Ep. 5.18, “Here Kitty”)
Character: a woman convinced that she’s going to die because a cat with a disconcerting tendency to sleep next to people on the last night of their lives slept next to her.

Mos Def (Ep. 5.19, “Locked In”)
Character: a guy who gets into a bicycle accident and gets locked-in syndrome for this trouble, meaning that he can think and is fully aware but can’t move or tell anyone of his awareness.

Meat Loaf (Ep. 5.20, “Simple Explanation”)
Character: a terminal patient who, like his life’s not bad enough already, has to endure watching his wife start to succumb to a resperatory ailment.

Carl Reiner (Ep. 5.24, “Both Sides Now”)
Character: an elderly man who claims to have a “squawking ” problem – his term for acid reflux, apparently – but actually has pancreatic cancer.

Curtis Armstrong (Ep. 6.1, “Broken”)
Character: One of House’s fellow patients at Mayfield Psychiatric Hospital.

James Earl Jones (Ep. 6.3, “The Tyrant”)
Character: a dying African dictator who nobody wants to save because he’s pro-ethnic-cleansing. Can you blame them, though? I mean, really…

Joshua Malina (Ep. 6.9, “Wilson”)
Character: a former patient of Wilson’s who asks him for part of his liver and, after getting it, proceeds to prove himself to be as much of a user as House is.

Ethan Embry (Ep. 6.10, “The Down Low”)
Character: a drug dealer suffering from the repeated aneurysms brought on by Hughes-Stovin Syndrome.

Orlando Jones (Ep. 6.12, “Moving the Chains”)
Character: Foreman’s brother. They’re not real close.

Laura Prepon (Ep. 6.14, “Private Lives”)
Character: A workaholic blogger with a case of Whipple’s Disease. It’s a gastrointestinal disorder. Any more detail would just freak us both out.

Sarah Wayne Callies (Ep. 6.18, “Open and Shut”)
Character: a woman whose open marriage makes it decidedly difficult to determine her ailment.

Jennifer Grey (Ep. 7.5, “Unplanned Parenthood”)
Character: a woman who gives birth to a baby with breathing problems, only to find out that she has melanoma and has passed it on to her child.

Amy Irving (Ep. 7.3, “Unwritten”)
Character: the author of a popular series of children’s books who has a seizure in the middle of trying to commit suicide.

Jack Coleman (Ep. 7.6, “Office Politics”)
Character: a senator’s campaign manager who has kidney failure. Oh, also, he probably had sex with the senator.

Matthew Lillard (Ep. 7.9, “Larger Than Life”)
Character: a musician who learns that parents aren’t fucking around when they tell you that chicken pox can be a major hassle when contracted by adults.

Donal Logue (Ep. 7.20, “Changes”)
Character: a lottery winner whose paralysis and cancer may or may not be the result of his new millionaire lifestyle.

David Costabile (Ep. 7.20, “Changes”)
Character: the lottery winner’s shady cousin.

Michael Pare (Ep. 8.1, “Twenty Vicodin”)
Character: The warden of the prison House gets thrown in after driving his car into Cuddy’s house.

Wentworth Miller (Ep. 8.3, “Charity Case”)
Character: a philanthropist who, in the midst of his own medical issues, offers to donate a kidney to a patient.

Michael Nouri (Ep. 8.4, “Risky Business”)
Character: a businessman whose constant trips to China may be the cause of his medical woes.

Billy Connolly (Ep. 8.14, “Love is Blind”)
Character: the man who would be House’s next stepfather. (In other words, the guy’s sleeping with House’s mom.)

Peter Weller (Ep. 8.20, “Post Mortem”)
Character: another physician at the hospital, one who looks suspiciously like the man who directed this episode.

James LeGros (Ep. 8.22, “Everybody Dies”)
Character: a drug addict who causes House to reflect on his life.

Chi McBride (Season 1)
Character: a billionaire pharmaceutical company owner who donates US$100 million to the hospital in return for becoming chairman of the board. He doesn’t like House. At all. Which is why he leaves quickly.

Sela Ward (Seasons 1 & 2)
Character: House’s ex-girlfriend, who turns up because she wants him to treat her husband, who’s suffering from acute intermittent porphyria. House thinks he’s going to get back together with his ex. He’s wrong.

Charles S. Dutton (Seasons 2 & 3)
Character: Foreman’s rather religious father.

R. Lee Ermey (Seasons 2 & 5)
Character: House’s father. Except it later turns out that he wasn’t actually House’s father after all. But that doesn’t stop him from grieving when he dies.

Diane Baker ( Seasons 2, 5 & 8 )
Character: House’s mother. Things get weird when she finds someone new in the wake of her husband’s death.

David Morse (Season 3)
Character: a clinic patient of House’s who gets pissed off at the way House treats him, and because he’s a detective, he proceeds to make House’s life a living hell for several episodes.

Leighton Meester (Season 3)
Character: House’s stalker. Actually, she only stalked him for two episodes, but it still technically counts.

Kadeem Hardison (Season 3)
Character: House’s attorney while he’s being taunted by David Morse’s character

Fred Durst (Season 4)
Character: the bartender who took House’s keys and forced him to ride the bus home, which subsequently wrecked and killed Amber (Anne Dudek), Wilson’s girlfriend.

Lori Petty (Season 5)
Character: a patient involved in the Huntington’s disease drug trials with Thirteen.

Andre Braugher (Season 6)
Character: House’s therapist when he’s doin’ time at the Mayfield Psychiatric Hospital. The two end up bonding somewhat after House’s release.

Cynthia Watros (Seasons 6 & 7)
Character: Wilson’s first wife. They start dating again. It doesn’t work out. Again.

Candice Bergen (Season 7)
Character: Cuddy’s mother

Paula Marshall (Season 7)
Character: Cuddy’s sister.